Early B cell development and commitment to the B cell lineage occurs in the foetal liver prenatally, before continuing in the bone marrow throughout life. B cells are at the centre of the adaptive humoral immune system and are responsible for mediating the production of antigen-specific immunoglobulin Ig directed against invasive pathogens typically known as antibodies. Several distinct B-cell subsets have been defined that possess distinct functions in both adaptive and innate humoral immune responses. Immunoglobulins consist of two identical heavy and light chains, which are joined by disulphide bonds.
B-Cells in Your Immune System
B-Cells in Your Immune System Help Fight Off Infections
Your browser does not have JavaScript enabled and some parts of this website will not work without it. For the best experience on the Abcam website please upgrade to a modern browser such as Google Chrome. Our Cookie Policy explains how you can opt-out of the cookies we use. B cells are mediators of the humoral response, or antibody-mediated immunity. By studying this particular cell group we learn more about the inner workings of the immune system, which consequently increases our awareness of the possible causes behind a variety of autoimmune disorders and cancers. Broad immunological research unlocks valuable insight of what future steps might be taken to treat these pathologies.
B cell life span: a review
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Transitional B cells are B cells at an intermediate stage in their development between bone marrow immature cells and mature B cells in the spleen. Primary B cell development takes place in the bone marrow , where immature B cells must generate a functional B cell receptor BCR and overcome negative selection induced by reactivity with autoantigens. The term "transitional B cell" was first used in mouse in for cells that are developmentally intermediate between immature bone marrow B lineage cells and fully mature naive B cells in the peripheral blood and secondary lymphoid tissues. It is postulated that the transitional cells, after leaving the bone marrow, are subjected to peripheral checks to prevent the production of autoantibodies. There are two transitional stages for the B cells in mouse, T1 and T2, with the T1 stage occurring from its migration from the bone marrow to its entry into the spleen, and the T2 stage occurring within the spleen where they developed into mature B cells.
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